Category: Nootropics

Magnesium L-threonate trials used 1,500-2,000 mg a day of Magtein, delivering only about 144 mg of elemental magnesium, in small studies.

Omega-3 cognitive trials used 500-2,000 mg a day of combined EPA and DHA for 6-24 months, and mostly found no benefit in healthy older adults.

No bacopa monnieri trial tested morning versus evening dosing. Take it with food, daily, for at least 12 weeks — that is what the evidence supports.

There is no trial on when to take lion’s mane. Here is the pharmacokinetic reasoning, and what matters far more than the hour you take it.

L-theanine timing: no trial has tested time of day. Take 200 mg about an hour before the task — the effect is acute, not cumulative.

Alpha-GPC dosage in almost every clinical trial was 1,200 mg a day, in dementia patients – and the compound carries a large stroke signal.

Creatine dosage in cognitive trials ran 3-20 g a day, and the memory effect was concentrated in adults aged 66-76, not in young people.

Citicoline dosage in trials was 250-500 mg a day in healthy adults and 500-1,000 mg in clinical work. Here is which trial each number came from.

Bacopa monnieri dosage in the trials was 300-450 mg a day of a 50% bacoside extract for at least 12 weeks. Here is where each number came from.

Lion’s mane trials used up to 3 g a day for 4 to 16 weeks, and only one of the seven reported its dose clearly. Here is what each gave.