Category: Evidence Guides
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Perimenopause brain fog is real, measurable and usually time-limited. What the SWAN and KEEPS trials found, and what no supplement has shown.
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CoQ10 has eight human cognitive trials, about half of them null, and its biggest high-dose neurological trial was stopped for futility.
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Cocoa flavanols and memory: COSMOS tested 500 mg a day for three years in over 5,700 people and found no cognitive effect at all.
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Vitamin D and cognition: observational studies link low levels to dementia risk, but randomized trials including VitaMIND found no cognitive benefit.
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Folate and B vitamins did not slow cognitive aging across 11 trials and 22,000 people, but one subgroup with high homocysteine did benefit.
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Third-party testing verifies that a supplement contains what its label says and no banned contaminants. It does not verify that the ingredient works.
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A proprietary blend legally hides every per-ingredient dose. Here is the regulation that permits it, and how to read a label around it.
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Two prevention trials of ginkgo, GEM and GuidAge, enrolled almost 6,000 people between them over five to six years. Neither reduced dementia.
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Racetams, noopept and phenibut are not lawful US dietary ingredients. FDA has issued warning letters, and one analysis found five such drugs in supplements.
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FDA concluded vinpocetine is not a lawful dietary ingredient and warned women of childbearing age to avoid it. Here is the documentation.